Speakers: Dr. Luca CONTARDO, Dr. Giuseppe PERINETTI Lecture held within the 3rd International Congress of the Croatian Society of Orthodontics. http://www.hdo-cso2016.org/eng-default.asp ABSTRACT Current evidence has shown that functional treatment for skeletal Class II malocclusion, irrespective of the used fixed or removable appliances, may be effective with clinically relevant skeletal effects if performed during the pubertal growth phase. While growth indicators have a primary role in the identification of the pubertal growth phase in individual patients, these indicators also suffer limitations in terms of reliability, repeatability or invasiveness. A logical combination use of several indicators in individual patients may be useful in the proper identification of the different growth phase making the treatment more efficient.